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John L. Rinn is an assistant professor of pathology
at Harvard Medical School and Beth Israel
Deaconess Medical Center and an associate
member of the Broad Institute. His research
aims to understand the role of large non-coding
RNA in establishing the distinct epigenetic
states of adult and embryonic cells and
their misregulation in cancer. By exploiting
multiple high-throughput genomic technologies
his group is actively discovering and
functionally characterizing an abundance
of these mysterious molecules throughout
the human genome. This work has revealed
the ability of large non-coding RNAs to
act in trans to silence large genomic
regions via association with polycomb
group complexes that could be further
developed as novel cancer therapeutics
that target and silence overactive oncogenes
in cancer.
Email
:
johnrinn@gmail.com
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