Quick Lincs

NEWS

 

 

 

 

 

 

 

John L. Rinn is an assistant professor of Stem Cell and Regerative Biology at Harvard University and Medical School and Senior Associate Member of the Broad Institute. Our research aims to understand the role of long non-coding RNAs (lncRNAs) in establishing the distinct epigenetic states of adult and embryonic cells and their misregulation in diseases such as cancer. To further explore how lncRNAs may define and or drive cell fate decisions we developed computational methods to provide initial hypothesis of their functions. This “guilt by association method” pointed to a clear connection of lncRNAs and numerous cellular pathways ranging from pluripotency, cancer, adipogenesis to parasitology. We have employed systematic compuational and experimental approaches that have unraveled a myriad of functional roles for lncRNAs in these pathways. Collectively our studies point to key regulatory roles for lncRNAs across diverse biological pathways, with a common theme of forming ribonucleic-protein complexes that in turn modulate cell fate decisions. Overall, we aim to understand lncRNAs physiological and disease roles in vivo from Mouse Models to Molecular Mechanisms.

NEWS